Application for Multi-Center Research Grant - Instructions

	The attached forms are to be used for all proposals. They should be completed in full and submitted by the Principal Investigator on behalf of all the partners.
	Applicants should carefully review the Hebrew guidelines.
	To enable prompt evaluation of your application, provide all details requested.
	Include a header in which pages are numbered consecutively from page 1. This numbering should replace the temporary page numbers on the forms. In the header, include the name of the PI on all pages.
	Maximum page lengths must not be exceeded
	No addenda or appendices of any type will be accepted
	Twelve sets of the proposal must reach the office of the National Institute for Psychobiology in Israel by the deadline which is December 15, 1997.

The application forms consist of the following:

Part I - General Information
Part II - Abstract
Part III - Project Schedule / Work Plan
Part IV - Detailed Description of the Proposed Project.
Part V - Curriculum Vitae and List of Publications of the PI and Co-PIÕs
Part VI - Budget
Part VII - Documents

Mailing Address:

SPECIFIC INSTRUCTIONS:

Part I - General Information

1. Fill in all details carefully and completely.
2. Note that signature of the PI and Authorized Official of the institution attest to the fact that all information contained in the proposal is accurate.
3. With regard to Part I.9 (Other Support and Financial Resources for Research), please note the following:
   

The information requested in this section is required for two purposes:

a)

To insure that there is no direct overlap in research funding i.e. that research funded from other competitive sources is not funded concurrently by the Center.

b)

To establish that the investigators have access to financial resources for research on Alzheimer's disease and related disorders which is at least equal to the sum requested from the Center. This is in compliance with the condition of matching funds established by the donor. The source of these financial resources may be one or more of the following: Competitive research grants which do not directly overlap with the project funded by the Center, institutional support in the form of stipends for students and/or direct non-competitive funding of research (but not salaries of investigators, laboratory technicians or other personnel nor equipment purchased by the institution), funds from donors, interest on endowments and other research funds, contracts with industry. Funding from these sources available to the PI and/or Co-Is (in any combination) will satisfy the matching requirement provided that it equals the amount requested from the Center to the research project.

Therefore, information is requested for the two categories of funding mentioned above i.e.:

1. Briefly describe the Scientific and Technological Background of the project.
   
2. Succinctly summarize the Objectives and Potential Significance of the project
   
3. Explain the Clinical Relevance of the project.
   
4. Enunciate the Working Hypothesis(es) of the project.
   
5. Describe the Plan of Operation and Methodology of the project (Start with a brief overview before proceeding to specific details)..
   
6. Clearly explain the Mode of Cooperation and Division of Responsibility among the participating groups. This section should clarify how the collaboration will work in practice, how the contributions of the groups will complement and supplement each other and how they will be coordinated..
   
7. Outline the Available Resources of the participating groups including personnel and equipment. Describe clinical resources clearly i.e. patient samples etc.
   
   The total pages of items 1 through 7 should not exceed ten pages.
   
   
8. Relevant Bibliography on the research area (Cite in text by numbers; for >3 authors et al. may be used; give full names of papers) (3 pages maximum).
   

Part V - Curriculum Vitae and List of Publications of the PI and Co-PIÕs

Provide curriculum vitae of the Principal and Co-Principal Investigators and list of selected, relevant publications (cv and publications together - maximum of two pages for each individual)


Part VI - Budget

The budget should be calculated in US dollars. Do not add correction for inflation for second and third years.

A. Salaries:

i.	Include all personnel participating in the project whether or not salary is requested. List individuals in the same order as in the forms in Part I. Include personnel not yet appointed if salary is requested for them.
ii.	Investigators from the permanent staff of the grantee institution(s) including the PI and Co-PIs are not entitled to receive salaries from the project.
iii.	Indicate role (Principal Investigator Ð PI; Co-Principal Investigator - Co-PI.; Co-investigator - CI, Technician Ð Tech.; Stud - Student, etc.).
iv.	Include social benefits in salary calculations

B. Equipment:
Limited equipment purchase may be approved for the first year only, provided it is very clearly justified.

C. Expendable materials etc.
Provide a calculations based on unit costs and quantities required in the budget justification section.

D. Other Expenses etc.

Clearly justify all expenses especially those which are unusual

Costs for consultants and external services must be clearly explained and justified and a letter from the consultant or service provider must be included in Part VI.

Overseas travel will not be approved.

E. Budget Justification

Provide brief category by category justification for all budget items using the same numbering system as in the budget tables.


Part VII - Documents

Include Certification of Helsinki Committee and/or Animal Use Committee, Letters from Consultants/External Collaborators, etc.)

If Helsinki and/or Animal Use certification is pending, include a letter indicating this (Certification must be received by September 30, 2001).